All disease begins in the (leaky) gut: role of zonulin-mediated gut permeability in the pathogenesis of some chronic inflammatory diseases
Abstract Improved hygiene leading to reduced exposure to microorganisms has been implicated as one possible cause for the recent “epidemic” of chronic inflammatory diseases (CIDs) in industrialized countries. That is the essence of the hygiene hypothesis that argues that rising [...]
Trifolium Repens Blocks Proliferation in Chronic Myelogenous Leukemia via the BCR-ABL/STAT5 Pathway
Abstract Some species of clover are reported to have beneficial effects in human diseases. However, little is known about the activity of the forage plant Trifolium repens, or white clover, which has been recently found to exert a hepatoprotective action. Scientific [...]
Indole-3-lactic acid, a metabolite of tryptophan, secreted by Bifidobacterium longum subspecies infantis is anti-inflammatory in the immature intestine
Abstract Background Necrotizing enterocolitis (NEC), a necrotic inflammation of the intestine, represents a major health problem in the very premature infant. Although prevention is difficult, the combination of ingestion of maternal-expressed breastmilk in conjunction with a probiotic provides the best [...]
Shortage of vital children’s cancer drug stirs fear and outrage
A critical shortage of a chemotherapy used to treat most childhood cancers has galvanized oncologists and parents of sick children. The U.S. medical community has become increasingly accustomed to dealing with chronic shortages of mainstay drugs, but vincristine is irreplaceable—and a big [...]
Some Radiaton-Drug combos just make side effects worse
Taking certain cancer-fighting drugs while undergoing radiation therapy may not increase survival, but could instead increase side effects, according new study. The drugs may still benefit patients who aren’t undergoing radiation therapy, say the researchers. In a meta-analysis, researchers find [...]
Modified drug combination may reduce risk of recurrence for some breast cancer patients
Masey Ross, M.D., and Charles Geyer, Jr., M.D. Credit: VCU Massey Cancer Center Oncologists at VCU Massey Cancer Center were invited to co-author an editorial published in the Journal of Clinical Oncology providing expert commentary on findings from a large [...]
Up and down the ladder: The latest comings and goings
Hired someone new and exciting? Promoting a rising star? Finally solved that hard-to-fill spot? Share the news with us, and we’ll share it with others. That’s right. Send us your changes, and we’ll find a home for them. Don’t be shy. [...]
Researchers develop model to personalize radiation treatment
A personalized approach to cancer treatment has become more common over the last several decades, with numerous targeted drugs approved to treat particular tumor types with specific mutations or patterns. However, this same personalized strategy has not translated to radiation [...]
Patient preferences explored in multiple myeloma treatment
(HealthDay)—An Eastern Cooperative Oncology Group (ECOG) performance status of ≥2 is linked to lower treatment satisfaction in patients with relapsed or refractory multiple myeloma (RRMM), but receiving medication orally is linked to higher satisfaction, according to a study published online [...]
Many clinical trials for new cancer drugs didn’t include any data on race
One-third of the clinical trials that led to new cancer drugs approved between 2008 and 2018 didn’t report on the race of trial participants — and even studies that did report on race often had far fewer black and Hispanic [...]
Drug May Aid People With Advanced Thyroid Cancer
MONDAY, Aug. 13 (HealthDay News) -- A new study shows that the chemotherapy drug vandetanib (Caprelsa) may extend life a bit for some thyroid cancer patients. The results of phase 2 trials showed that patients taking the drug lived for 11 months without the cancer progressing, [...]
How Amgen plans to BiTE into CAR-T’s hype
While personalized CAR-T cancer therapies make headlines in biotech, Amgen has been betting big on another tumor-killing approach with, yes, another acronym: BiTEs. The trademarked term stands for a bi-specific T-cell engager — an antibody that can grab both immune cells [...]
When the cardiology patient ends up in the oncology care ward
New research shows what can happen with patients in 'off-service' hospital beds. If you end up needing to go to the hospital, often times you're hoping to get a bed without having to wait hours, but a new study shows [...]
Study finds lack of racial diversity in cancer drug clinical trials
New research published this week in JAMA Oncology has found a lack of racial and ethnic diversity in clinical trials for cancer drugs. The study—conducted by researchers from UBC, the University of Texas MD Anderson Cancer Center, the Fred Hutchinson Cancer Center [...]
New drug shows encouraging survival in pancreatic cancer
A clinical trial testing a new drug in pancreatic cancer had promising initial results, report researchers from the University of Michigan Rogel Cancer Center. A phase 1 clinical trial looked at AZD1775, an inhibitor designed to block an enzyme called [...]
