Development and Validation of a Serum Metabolomic Signature for Endometrial Cancer Screening in Postmenopausal Women
Key Points Question Is combining the blood metabolomic signature of endometrial carcinoma with an ensemble machine learning algorithm a useful system for building a screening test for endometrial cancer? Findings In this diagnostic study that included 1550 postmenopausal women, the proposed screening [...]
Development and Validation of a Serum Metabolomic Signature for Endometrial Cancer Screening in Postmenopausal Women
Abstract Importance Endometrial carcinoma (EC) is the most commonly diagnosed gynecologic cancer. Its early detection is advisable because 20% of women have advanced disease at the time of diagnosis. Objective To clinically validate a metabolomics-based classification algorithm as a screening test for [...]
Altered lung tissue lipidomic profile in caspase-4 positive non-small cell lung cancer (NSCLC) patients
Lung cancer is by far the leading cause of cancer death. Metabolomic studies have highlighted that both tumor progression and limited curative treatment options are partly due to dysregulated glucose metabolism and its associated signaling pathways. In our previous studies, [...]
Zonulin-Dependent Intestinal Permeability in Children Diagnosed with Mental Disorders: A Systematic Review and Meta-Analysis
Abstract Worldwide, up to 20% of children and adolescents experience mental disorders, which are the leading cause of disability in young people. Research shows that serum zonulin levels are associated with increased intestinal permeability (IP), affecting neural, hormonal, and immunological [...]
Analysis of immune, microbiota and metabolome maturation in infants in a clinical trial of Lactobacillus paracasei CBA L74-fermented formula
Abstract Mother’s milk is the best choice for infants nutrition, however when it is not available or insufficient to satisfy the needs of the infant, formula is proposed as an effective substitute. Here, we report the results of a randomized [...]
Citrus sinensis and Vitis vinifera Protect Cardiomyocytes from Doxorubicin-Induced Oxidative Stress: Evaluation of Onconutraceutical Potential of Vegetable Smoothies
Abstract The interest towards nutraceuticals able to counteract drug side effects is continuously growing in current chemotherapeutic protocols. In the present study, we demonstrated that smoothies containing mixtures of Citrus sinensis and Vitis vinifera L. cv. Aglianico N, two typical fruits of the Mediterranean [...]
Clues to Autism’s Origins
Abnormally low levels of a key protein observed in brains of young men with autism spectrum disorder. A neuroimaging study by Harvard Medical School researchers based at Massachusetts General Hospital has shown that the brains of young men with autism [...]
Iron Overload Mimicking Conditions Skews Bone Marrow Dendritic Cells Differentiation into MHCIIlowCD11c+CD11b+F4/80+ Cells
Abstract Iron overload is an undesired effect of frequent blood transfusions or genetic diseases. Myelodysplastic syndrome (MDS) patients become transfusion dependent, but due to the combination of ineffective haematopoiesis and repeated blood transfusions they are often subject to iron overload. [...]
All disease begins in the (leaky) gut: role of zonulin-mediated gut permeability in the pathogenesis of some chronic inflammatory diseases
Abstract Improved hygiene leading to reduced exposure to microorganisms has been implicated as one possible cause for the recent “epidemic” of chronic inflammatory diseases (CIDs) in industrialized countries. That is the essence of the hygiene hypothesis that argues that rising [...]
Trifolium Repens Blocks Proliferation in Chronic Myelogenous Leukemia via the BCR-ABL/STAT5 Pathway
Abstract Some species of clover are reported to have beneficial effects in human diseases. However, little is known about the activity of the forage plant Trifolium repens, or white clover, which has been recently found to exert a hepatoprotective action. Scientific [...]
Indole-3-lactic acid, a metabolite of tryptophan, secreted by Bifidobacterium longum subspecies infantis is anti-inflammatory in the immature intestine
Abstract Background Necrotizing enterocolitis (NEC), a necrotic inflammation of the intestine, represents a major health problem in the very premature infant. Although prevention is difficult, the combination of ingestion of maternal-expressed breastmilk in conjunction with a probiotic provides the best [...]
Shortage of vital children’s cancer drug stirs fear and outrage
A critical shortage of a chemotherapy used to treat most childhood cancers has galvanized oncologists and parents of sick children. The U.S. medical community has become increasingly accustomed to dealing with chronic shortages of mainstay drugs, but vincristine is irreplaceable—and a big [...]
Some Radiaton-Drug combos just make side effects worse
Taking certain cancer-fighting drugs while undergoing radiation therapy may not increase survival, but could instead increase side effects, according new study. The drugs may still benefit patients who aren’t undergoing radiation therapy, say the researchers. In a meta-analysis, researchers find [...]
Modified drug combination may reduce risk of recurrence for some breast cancer patients
Masey Ross, M.D., and Charles Geyer, Jr., M.D. Credit: VCU Massey Cancer Center Oncologists at VCU Massey Cancer Center were invited to co-author an editorial published in the Journal of Clinical Oncology providing expert commentary on findings from a large [...]
Up and down the ladder: The latest comings and goings
Hired someone new and exciting? Promoting a rising star? Finally solved that hard-to-fill spot? Share the news with us, and we’ll share it with others. That’s right. Send us your changes, and we’ll find a home for them. Don’t be shy. [...]
