Zonulin as a Biomarker for the Development of Celiac Disease
Abstract Objectives: Increased intestinal permeability seems to be a key factor in the pathogenesis of autoimmune diseases, including celiac disease (CeD). However, it is unknown whether increased permeability precedes CeD onset. This study's objective was to determine whether intestinal permeability is [...]
A narrative review of digital biomarkers in the management of major depressive disorder and treatment-resistant forms
Introduction: Depression is the leading cause of worldwide disability, until now only 3% of patients with major depressive disorder (MDD) experiences full recovery or remission. Different studies have tried to better understand MDD pathophysiology and its resistant forms (TRD), focusing on [...]
Approccio integrato nel trattamento riabilitativo individualizzato degli esordi psicotici: l’efficacia di lurasidone sul funzionamento nella vita reale
Approccio integrato nel trattamento riabilitativo individualizzato degli esordi psicotici: l’efficacia di lurasidone sul funzionamento nella vita reale. Leggi l'articolo completo al link
Editorial: Psychometrics in psychiatry 2022: psychological therapy and psychosomatics
Editorial on the Research Topic Psychometrics in psychiatry 2022: psychological therapy and psychosomatics The importance of evidence-based assessment and measurement in mental healthcare has become increasingly recognized in recent decades. However, psychiatry has long grappled with challenges in quantifying subjective [...]
Balancing risks and benefits of cannabis use: umbrella review of meta-analyses of randomised controlled trials and observational studies
Abstract Objective To systematically assess credibility and certainty of associations between cannabis, cannabinoids, and cannabis based medicines and human health, from observational studies and randomised controlled trials (RCTs). Design Umbrella review. Data sources PubMed, PsychInfo, Embase, up to 9 February [...]
Incidence, prevalence, and global burden of schizophrenia – data, with critical appraisal, from the Global Burden of Disease (GBD) 2019
Abstract Schizophrenia substantially contributes to the burden of mental disorders. Schizophrenia’s burden and epidemiological estimates in some countries have been published, but updated estimates of prevalence, incidence, and schizophrenia-related disability at the global level are lacking. Here, we present the [...]
Early Antibody Dynamics in a Prospective Cohort of Children At Risk of Celiac Disease
Abstract INTRODUCTION: The purpose of this study was to identify possible serum biomarkers predicting celiac disease (CD) onset in children at risk. METHODS: A subgroup from an ongoing, international prospective study of children at risk of CD was classified according [...]
In Silico Identification and In Vitro Evaluation of New ABCG2 Transporter Inhibitors as Potential Anticancer Agents
Abstract Different molecular mechanisms contribute to the development of multidrug resistance in cancer, including increased drug efflux, enhanced cellular repair mechanisms and alterations of drug metabolism or drug targets. ABCG2 is a member of the ATP-binding cassette superfamily transporters that [...]
Drug Resistance: The Role of Exosomal miRNA in the Microenvironment of Hematopoietic Tumors
Abstract Extracellular vesicles (EVs), including exosomes, have an important role thanks to their ability to communicate and exchange information between tumor cells and the tumor microenvironment (TME), and have also been associated with communicating anti-cancer drug resistance (DR). The increase [...]
Editorial: Novel Strategies in Drug Development Against Multifactorial Diseases
Editorial on the Research Topic Novel Strategies in Drug Development Against Multifactorial Diseases The complexity of multifactorial diseases, such as inflammation, cancer, neurodegenerative disorders, infectious pathologies represents a key obstacle in the success of therapeutic intervention. The occurrence of acquired [...]
Corrigendum: Overcome Chemoresistance: Biophysical and Structural Analysis of Synthetic FHIT-Derived Peptides
A Corrigendum on Overcome Chemoresistance: Biophysical and Structural Analysis of Synthetic FHIT-Derived Peptides by Scala, M. C., Di Micco, S., Lanzillotta, D., Musella, S., Di Sarno, V., Parrino, B., Cascioferro, S. M., Bifulco, G., Trapasso, F., Campiglia, P., and Sala, [...]
Discovery and Optimization of Indoline-Based Compounds as Dual 5-LOX/sEH Inhibitors: In Vitro and In Vivo Anti-Inflammatory Characterization
Abstract The design of multitarget drugs represents a promising strategy in medicinal chemistry and seems particularly suitable for the discovery of anti-inflammatory drugs. Here, we describe the identification of an indoline-based compound inhibiting both 5-lipoxygenase (5-LOX) and soluble epoxide hydrolase [...]
Extensive Molecular Dynamics Simulations Disclosed the Stability of mPGES-1 Enzyme and the Structural Role of Glutathione (GSH) Cofactor
Abstract A deep in silico investigation of various microsomal prostaglandin E2 synthase-1 (mPGES-1) protein systems is here reported using molecular dynamics (MD) simulations. Firstly, eight different proteins models (Models A−H) were built, starting from the active enzyme trimer system (Model A), [...]
Identification of 2,4-Dinitro-Biphenyl-Based Compounds as MAPEG Inhibitors
Abstract Multipronged strategy: 2,4-Dinitro-biphenyl-based compounds were identified as inhibitors of leukotriene C4 synthase (LTC4S) and 5-lipoxygenase-activating protein (FLAP), both members of the “Membrane Associated Proteins in Eicosanoid and Glutathione metabolism” (MAPEG) family involved in the biosynthesis of pro-inflammatory eicosanoids. The results [...]
Rational design of the zonulin inhibitor AT1001 derivatives as potential anti SARS-CoV-2
Abstract Although vaccines are greatly mitigating the worldwide pandemic diffusion of SARS-Cov-2, therapeutics should provide many distinct advantages as complementary approach to control the viral spreading. Here, we report the development of new tripeptide derivatives of AT1001 against SARS-CoV-2 Mpro. [...]
