Identification of Honokiol-Based Scaffold to Design Tankyrase 1/2 Inhibitors by In Silico and In Vitro Studies
Abstract Recently, we identified magnolol bioinspired derivatives as new Tankyrase 1/2 (TNKS1/2) inhibitors by our Inverse Virtual Screening protocol. Based on these findings, in the present contribution, we enlarged our investigation of neolignans to the natural product honokiol (1) and [...]
METABOLIC MANAGEMENT MODEL IN PSYCHIATRIC OUTPATIENTS: A REAL-WORLD EXPERIENCE
Summary Obesity and weight gain represent a challenging issue in people suffering from schizophrenia and other severe mental illnesses (SMI). Most of clinical guidelines for the management of overweight and obesity in people with SMI share a stepwise approach starting [...]
Global and risk-group stratified well-being and mental health during the COVID-19 pandemic in adults: Results from the international COH-FIT Study
Abstract International studies measuring wellbeing/multidimensional mental health before/ during the COVID-19 pandemic, including representative samples for >2 years, identifying risk groups and coping strategies are lacking. COH-FIT is an online, international, anonymous survey measuring changes in well-being (WHO-5) and a [...]
Collaborative outcomes study on health and functioning during infection times (COH-FIT): Insights on modifiable and non-modifiable risk and protective factors for wellbeing and mental health during the COVID-19 pandemic from multivariable and network analyses
Abstract There is no multi-country/multi-language study testing a-priori multivariable associations between non- modifiable/modifiable factors and validated wellbeing/multidimensional mental health outcomes before/during the COVID-19 pandemic. Moreover, studies during COVID-19 pandemic generally do not report on sentative/weighted non-probability samples. The Collaborative Outcomes [...]
Enhancing the treatment of eating disorders: insights and challenges from the Regional Residential Center “Mariconda” in Salerno
Summary Objective. Eating Disorders are serious psychological conditions causing significant physical and mental health impairments. They have high mortality and suicide rates, and many affected individuals do not receive adequate treatment. Aim. This study aimed to evaluate the preliminary results [...]
An advanced Artificial Intelligence platform for a personalised treatment of Eating Disorders
Abstract Introduction: Eating Disorders (EDs) affect individuals globally and are associated with significant physical and mental health challenges. However, access to adequate treatment is often hindered by societal stigma, limited awareness, and resource constraints. Methods: The project aims to utilize [...]
Exploring the Efficacy of Lurasidone as an Adjunct to Fluvoxamine in the Treatment of Obsessive-Compulsive Disorder with Comorbid Restrictive Anorexia Nervosa: A Case Report
Abstract Introduction: Eating Disorders (EDs) significantly impact quality of life and social functioning, with varying prevalence rates and a recent rise in diagnosis due to the COVID-19 pandemic. Anorexia Nervosa (AN) frequently co-occurs with Obsessive-Compulsive Disorder (OCD), and this comorbidity [...]
Optimizing and Predicting Antidepressant Efficacy in Patients with Major Depressive Disorder Using Multi-Omics Analysis and the Opade AI Prediction Tools
Abstract According to the World Health Organization (WHO), major depressive disorder (MDD) is the fourth leading cause of disability worldwide and the second most common disease after cardiovascular events. Approximately 280 million people live with MDD, with incidence varying by [...]
Innova4Health: an integrated approach for prevention of recurrence and personalized treatment of Major Depressive Disorder
Abstract Background: Major Depressive Disorder (MDD) is a prevalent mental health condition characterized by persistent low mood, cognitive and physical symptoms, anhedonia (loss of interest in activities), and suicidal ideation. The World Health Organization (WHO) predicts depression will become the leading [...]
Design, Synthesis, and Pharmacological Characterization of a Potent Soluble Epoxide Hydrolase Inhibitor for the Treatment of Acute Pancreatitis
Abstract Acute pancreatitis (AP) is a potentially life-threatening illness characterized by an exacerbated inflammatory response with limited options for pharmacological treatment. Here, we describe the rational development of a library of soluble epoxide hydrolase (sEH) inhibitors for the treatment of [...]
Novel pyrrole based CB2 agonists: New insights on CB2 receptor role in regulating neurotransmitters’ tone
Abstract The cannabinoid system is one of the most investigated neuromodulatory systems because of its involvement in multiple pathologies such as cancer, inflammation, and psychiatric diseases. Recently, the CB2 receptor has gained increased attention considering its crucial role in modulating [...]
Zonulin as a Biomarker for the Development of Celiac Disease
Abstract Objectives: Increased intestinal permeability seems to be a key factor in the pathogenesis of autoimmune diseases, including celiac disease (CeD). However, it is unknown whether increased permeability precedes CeD onset. This study's objective was to determine whether intestinal permeability is [...]
Outcomes in people with eating disorders: a transdiagnostic and disorder‐specific systematic review, meta‐analysis and multivariable meta‐regression analysis
Abstract Eating disorders (EDs) are known to be associated with high mortality and often chronic and severe course, but a recent comprehensive systematic review of their outcomes is currently missing. In the present systematic review and meta‐analysis, we examined cohort [...]
Zonulin as a Biomarker for the Development of Celiac Disease
Abstract Objectives: Increased intestinal permeability seems to be a key factor in the pathogenesis of autoimmune diseases, including celiac disease (CeD). However, it is unknown whether increased permeability precedes CeD onset. This study's objective was to determine whether intestinal permeability is [...]
A narrative review of digital biomarkers in the management of major depressive disorder and treatment-resistant forms
Introduction: Depression is the leading cause of worldwide disability, until now only 3% of patients with major depressive disorder (MDD) experiences full recovery or remission. Different studies have tried to better understand MDD pathophysiology and its resistant forms (TRD), focusing on [...]
