Early Antibody Dynamics in a Prospective Cohort of Children At Risk of Celiac Disease

INTRODUCTION: 

The purpose of this study was to identify possible serum biomarkers predicting celiac disease (CD) onset in children at risk.

METHODS: 

A subgroup from an ongoing, international prospective study of children at risk of CD was classified according to an early trajectory of deamidated gliadin peptides (DGPs) immunoglobulin (Ig) G and clinical outcomes (CD, potential CD, and CD autoimmunity).

RESULTS: 

Thirty-eight of 325 children developed anti-tissue transglutaminase IgA antibody (anti-tTG IgA) seroconversion. Twenty-eight of 38 children (73.6%) showed an increase in anti-DGPs IgG before their first anti-tTG IgA seroconversion.

DISCUSSION: 

Anti-DGPs IgG can represent an early preclinical biomarker predicting CD onset in children at risk.

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