An advanced Artificial Intelligence platform for a personalised treatment of Eating Disorders
Abstract Introduction: Eating Disorders (EDs) affect individuals globally and are associated with significant physical and mental health challenges. However, access to adequate treatment is often hindered by societal stigma, limited awareness, and resource constraints. Methods: The project aims to utilize [...]
Exploring the Efficacy of Lurasidone as an Adjunct to Fluvoxamine in the Treatment of Obsessive-Compulsive Disorder with Comorbid Restrictive Anorexia Nervosa: A Case Report
Abstract Introduction: Eating Disorders (EDs) significantly impact quality of life and social functioning, with varying prevalence rates and a recent rise in diagnosis due to the COVID-19 pandemic. Anorexia Nervosa (AN) frequently co-occurs with Obsessive-Compulsive Disorder (OCD), and this comorbidity [...]
Optimizing and Predicting Antidepressant Efficacy in Patients with Major Depressive Disorder Using Multi-Omics Analysis and the Opade AI Prediction Tools
Abstract According to the World Health Organization (WHO), major depressive disorder (MDD) is the fourth leading cause of disability worldwide and the second most common disease after cardiovascular events. Approximately 280 million people live with MDD, with incidence varying by [...]
Innova4Health: an integrated approach for prevention of recurrence and personalized treatment of Major Depressive Disorder
Abstract Background: Major Depressive Disorder (MDD) is a prevalent mental health condition characterized by persistent low mood, cognitive and physical symptoms, anhedonia (loss of interest in activities), and suicidal ideation. The World Health Organization (WHO) predicts depression will become the leading [...]
Design, Synthesis, and Pharmacological Characterization of a Potent Soluble Epoxide Hydrolase Inhibitor for the Treatment of Acute Pancreatitis
Abstract Acute pancreatitis (AP) is a potentially life-threatening illness characterized by an exacerbated inflammatory response with limited options for pharmacological treatment. Here, we describe the rational development of a library of soluble epoxide hydrolase (sEH) inhibitors for the treatment of [...]
Novel pyrrole based CB2 agonists: New insights on CB2 receptor role in regulating neurotransmitters’ tone
Abstract The cannabinoid system is one of the most investigated neuromodulatory systems because of its involvement in multiple pathologies such as cancer, inflammation, and psychiatric diseases. Recently, the CB2 receptor has gained increased attention considering its crucial role in modulating [...]
Zonulin as a Biomarker for the Development of Celiac Disease
Abstract Objectives: Increased intestinal permeability seems to be a key factor in the pathogenesis of autoimmune diseases, including celiac disease (CeD). However, it is unknown whether increased permeability precedes CeD onset. This study's objective was to determine whether intestinal permeability is [...]
Outcomes in people with eating disorders: a transdiagnostic and disorder‐specific systematic review, meta‐analysis and multivariable meta‐regression analysis
Abstract Eating disorders (EDs) are known to be associated with high mortality and often chronic and severe course, but a recent comprehensive systematic review of their outcomes is currently missing. In the present systematic review and meta‐analysis, we examined cohort [...]
Zonulin as a Biomarker for the Development of Celiac Disease
Abstract Objectives: Increased intestinal permeability seems to be a key factor in the pathogenesis of autoimmune diseases, including celiac disease (CeD). However, it is unknown whether increased permeability precedes CeD onset. This study's objective was to determine whether intestinal permeability is [...]
A narrative review of digital biomarkers in the management of major depressive disorder and treatment-resistant forms
Introduction: Depression is the leading cause of worldwide disability, until now only 3% of patients with major depressive disorder (MDD) experiences full recovery or remission. Different studies have tried to better understand MDD pathophysiology and its resistant forms (TRD), focusing on [...]
Approccio integrato nel trattamento riabilitativo individualizzato degli esordi psicotici: l’efficacia di lurasidone sul funzionamento nella vita reale
Approccio integrato nel trattamento riabilitativo individualizzato degli esordi psicotici: l’efficacia di lurasidone sul funzionamento nella vita reale. Leggi l'articolo completo al link
Editorial: Psychometrics in psychiatry 2022: psychological therapy and psychosomatics
Editorial on the Research Topic Psychometrics in psychiatry 2022: psychological therapy and psychosomatics The importance of evidence-based assessment and measurement in mental healthcare has become increasingly recognized in recent decades. However, psychiatry has long grappled with challenges in quantifying subjective [...]
Balancing risks and benefits of cannabis use: umbrella review of meta-analyses of randomised controlled trials and observational studies
Abstract Objective To systematically assess credibility and certainty of associations between cannabis, cannabinoids, and cannabis based medicines and human health, from observational studies and randomised controlled trials (RCTs). Design Umbrella review. Data sources PubMed, PsychInfo, Embase, up to 9 February [...]
Incidence, prevalence, and global burden of schizophrenia – data, with critical appraisal, from the Global Burden of Disease (GBD) 2019
Abstract Schizophrenia substantially contributes to the burden of mental disorders. Schizophrenia’s burden and epidemiological estimates in some countries have been published, but updated estimates of prevalence, incidence, and schizophrenia-related disability at the global level are lacking. Here, we present the [...]
Early Antibody Dynamics in a Prospective Cohort of Children At Risk of Celiac Disease
Abstract INTRODUCTION: The purpose of this study was to identify possible serum biomarkers predicting celiac disease (CD) onset in children at risk. METHODS: A subgroup from an ongoing, international prospective study of children at risk of CD was classified according [...]
